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Cat. No.: HY-182529

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DHPS-IN-3

DHPS-IN-3 (Compound 26d) is a NAD-competitive DHPS inhibitor, with an IC₅₀ of 0.0092 μM at 14 μM NAD and an IC₅₀ of 0.069 μM at 250 μM NAD. DHPS-IN-3 is applicable for cancer research.

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CAS No.: 2470012-40-7
화학식: C₁₈H₂₃N₃OS
분자량:329.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

DHPS-IN-3 Chemical Structure

CAS No.: 2470012-40-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
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Biological Activity

제품 설명

All DNA/RNA Synthesis Isoforms :

In Vitro

DHPS-IN-3 potently inhibits deoxyhypusine synthase with an IC₅₀ of 0.0092 μM at 14 μM NAD, showing a NAD-competitive inhibitory profile^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	V_dss	CL_total	C_max	MRT	F
Mice^[1]	0.1 mg/kg	i.v.	8491 mL/kg	8965 mL/h/kg	/	/	/
Mice^[1]	1 mg/kg	p.o.	/	/	4.8 ng/mL	2.46 h	11.7 %

Chemical Information

CAS No. 2470012-40-7
분자량 329.46
화학식 C₁₈H₂₃N₃OS
SMILES

O=C1C2=C(CCN1[C@@H](CN)CC(C)C)C(C3=CN=CC=C3)=CS2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Tanaka Y, et al. New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. ACS Med Chem Lett. 2020;11(8):1645-1652. Published 2020 Jul 30. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
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DHPS-IN-3

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DHPS-IN-3 Related Classifications

HY-182529 Related Classifications