Cdh2 - cadherin 2 Gene

Also Known as CDHN; Ncad; N-CAD

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12558

Summary

This gene encodes a member of the Cadherin family of calcium-dependent glycoproteins that mediate cell adhesion. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Mice lacking the encoded protein exhibit severe developmental defects resulting in embryonic death. [provided by RefSeq, Oct 2015]

Cdh2 Products (1)

mRNA Protein Name
NM_007664.5 NP_031690.3 cadherin-2 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
27783602 MGI
enables calcium ion binding IDA
IDA: Inferred from direct assay
9655503 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
24952463 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
20190754 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11106648 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
23392350 MGI
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
16973135 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
15809310 MGI
acts upstream of or within brain morphogenesis IGI
IGI: Inferred from genetic interaction
25100583 MGI
acts upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
14561752 MGI
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
12738802 MGI
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
14561752 MGI
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
9655503 MGI
involved in cell-cell adhesion mediated by cadherin IDA
IDA: Inferred from direct assay
24952463 MGI
involved in cell-cell junction assembly IMP
IMP: Inferred from mutant phenotype
26750727 MGI
acts upstream of or within cerebral cortex development IGI
IGI: Inferred from genetic interaction
25100583 MGI
involved in glial cell differentiation IDA
IDA: Inferred from direct assay
24952463 MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
8270638 MGI
acts upstream of or within homeostasis of number of cells IGI
IGI: Inferred from genetic interaction
25100583 MGI
acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
8270638 MGI
acts upstream of or within mesenchymal cell migration IMP
IMP: Inferred from mutant phenotype
17507657 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19075000 MGI
involved in neural crest cell development IMP
IMP: Inferred from mutant phenotype
26750727 MGI
acts upstream of or within neuroepithelial cell differentiation IGI
IGI: Inferred from genetic interaction
25100583 MGI
involved in neuroligin clustering involved in postsynaptic membrane assembly IMP
IMP: Inferred from mutant phenotype
20534458 MGI
involved in neuronal stem cell population maintenance IDA
IDA: Inferred from direct assay
24952463 MGI
acts upstream of or within positive regulation of MAPK cascade IGI
IGI: Inferred from genetic interaction
20160094 MGI
involved in positive regulation of synaptic vesicle clustering IMP
IMP: Inferred from mutant phenotype
20534458 MGI
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
24046456 MGI
acts upstream of or within radial glial cell differentiation IGI
IGI: Inferred from genetic interaction
25100583 MGI
acts upstream of or within regulation of oligodendrocyte progenitor proliferation IGI
IGI: Inferred from genetic interaction
25100583 MGI
involved in regulation of postsynaptic density protein 95 clustering IMP
IMP: Inferred from mutant phenotype
20534458 MGI
acts upstream of or within striated muscle cell differentiation IGI
IGI: Inferred from genetic interaction
20160094 MGI
involved in synaptic vesicle clustering IMP
IMP: Inferred from mutant phenotype
34702855 MGI
acts upstream of or within telencephalon development IGI
IGI: Inferred from genetic interaction
25100583 MGI
involved in type B pancreatic cell development IMP
IMP: Inferred from mutant phenotype
26750727 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
12052883 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
21947081 MGI
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
29211732 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
25512490 MGI
located in cell surface IDA
IDA: Inferred from direct assay
25232112 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
21296051 MGI
located in desmosome IDA
IDA: Inferred from direct assay
15479741 MGI
located in fascia adherens IDA
IDA: Inferred from direct assay
11732910 MGI
located in intercalated disc IDA
IDA: Inferred from direct assay
17884088 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
14657280 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9655503 MGI
located in plasma membrane raft IDA
IDA: Inferred from direct assay
24046456 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
23392350 MGI
located in synapse IDA
IDA: Inferred from direct assay
14622577 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cadherin-2

  • N-cadherin

  • neural cadherin

Recombinant Cdh2 Proteins

Cat. No. 상품명 Accession Purity
HY-P73750 N-Cadherin Protein, Mouse (HEK293) P15116 (S26-A724) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS02330 CDH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17634 Cdh2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24094 Cdh2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdh2 NCBI NCBI:1000