DAPP1 - dual adaptor of phosphotyrosine and 3-phosphoinositides 1 Gene

Also Known as BAM32

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27071

About DAPP1

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,816,827-99,872,333 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 16.8), appendix (RPKM 14.4) and 15 other tissues.

Summary

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in signal transduction. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

DAPP1 Products (2)

mRNA Protein Name
NM_001306151.2 NP_001293080.1 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 2
NM_014395.3 NP_055210.2 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
11001876 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
11001876 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25814554 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
17823121 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAPP1 Protein Structure

SH2

SH2: SH2 domain (35 - 109)

PH

PH: PH domain (167 - 255)

  • 0
  • 100
  • 200
  • 280 a.a.
Protein Preferred Names Protein Names

dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

  • B-cell adapter molecule of 32 kDa

DAPP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DAPP1 Q9UN19 WDR20 Homo sapiens Q8TBZ3
Y2H Array
25814554
Intra
DAPP1 Q9UN19 WDR20 Homo sapiens Q8TBZ3
Lumier
25814554
Intra
DAPP1 Q9UN19 APBB3 Homo sapiens O95704
Y2H Array
25814554
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS03531 DAPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DAPP1 RGD RGD:1310189
Mus musculus DAPP1 MGD MGI:1347063
Bos taurus DAPP1 VGNC VGNC:27880
Felis catus DAPP1 VGNC VGNC:61340
Canis familiaris DAPP1 VGNC VGNC:39773
Macaca mulatta DAPP1 VGNC VGNC:71630
Others DAPP1 NCBI