Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity

  • J Nat Prod. 2006 Feb;69(2):277-9. doi: 10.1021/np0503303.
Wei-Lie Xiao  1 ,  Ren-Rong Tian ,  Jian-Xin Pu ,  Xian Li ,  Li Wu ,  Yang Lu ,  Sheng-Hong Li ,  Rong-Tao Li ,  Yong-Tang Zheng ,  Qi-Tai Zheng ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
PMID: 16499331 DOI: 10.1021/np0503303
Abstract

A new trinorcycloartane triterpenoid, lancifodilactone H (1), and a new A ring-secocycloartane triterpenoid, lancifoic acid A (2), together with a known compound, nigranoic acid (3), were isolated from the leaves and stems of Schisandra lancifolia. Their structures were elucidated by spectroscopic data analysis. Compound 1 features a biosynthetically modified seven-membered lactone ring, which was confirmed by single-crystal X-ray diffraction. Compounds 1-3 exhibited weak anti-HIV-1 activity in vitro.