KV2 channel inhibitor-1
Based on 1 Customer Validation
KV2 channel inhibitor-1 is a selective KV2 channel inhibitor with IC50s of 0.2 μM and 0.41 μM for KV2.1 and KV2.2, respectively. KV2 channel inhibitor-1 possesses good selectivity over KV1.2 (IC50>10 μM). KV2 channel inhibitor-1 is >10-fold selective over NaV channels and other KV channels and displays weak activity on CaV channels.
For research use only. We do not sell to patients.
- Purity: 98.73%
- CAS No.: 689297-68-5
- Formula: C20H17ClN4OS
- Molecular Weight:396.89
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.2 μM (KV2.1), 0.41 μM (KV2.2), 12.1 μM (KV1.2), 9.5 μM (KV1.5), >20 μM (KV3.2), 2.9 μM (KV11.1), 6.6 μM (CaV1.2), >10 μM (CaV2.1), >10 μM (CaV2.2), 5.7 μM (CaV2.3), >10 μM (NaV1.5), 8 μM (NaV1.7)[1]
KV2 channel inhibitor-1 (compound A1; 0.3, 1, 3 μM; 0-3000s) inhibits the KV current in rat insulinoma INS-1 cells. KV2 channel inhibitor-1 blocks INS-1 KV current an average of 71% at 0.3 μM and 84% at 3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 689297-68-5
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Appearance Solid
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Molecular Weight 396.89
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Formula C20H17ClN4OS
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Color White to off-white
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SMILES
O=C(NC1=CC=C2N=C(C3=CSC=N3)NC2=C1)CC(C)C4=CC=CC(Cl)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (629.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5196 mL | 12.5979 mL | 25.1959 mL | 62.9897 mL |
| 5 mM | 0.5039 mL | 2.5196 mL | 5.0392 mL | 12.5979 mL | |
| 10 mM | 0.2520 mL | 1.2598 mL | 2.5196 mL | 6.2990 mL | |
| 15 mM | 0.1680 mL | 0.8399 mL | 1.6797 mL | 4.1993 mL | |
| 20 mM | 0.1260 mL | 0.6299 mL | 1.2598 mL | 3.1495 mL | |
| 25 mM | 0.1008 mL | 0.5039 mL | 1.0078 mL | 2.5196 mL | |
| 30 mM | 0.0840 mL | 0.4199 mL | 0.8399 mL | 2.0997 mL | |
| 40 mM | 0.0630 mL | 0.3149 mL | 0.6299 mL | 1.5747 mL | |
| 50 mM | 0.0504 mL | 0.2520 mL | 0.5039 mL | 1.2598 mL | |
| 60 mM | 0.0420 mL | 0.2100 mL | 0.4199 mL | 1.0498 mL | |
| 80 mM | 0.0315 mL | 0.1575 mL | 0.3149 mL | 0.7874 mL | |
| 100 mM | 0.0252 mL | 0.1260 mL | 0.2520 mL | 0.6299 mL |
KV2 channel inhibitor-1 Related Classifications
HY-44153 Related Classifications
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