L-Serine-O-sulfate potassium

Cat. No.: HY-W115558: Data Sheet
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L-Serine-O-sulfate potassium is a serine racemase (Srr) inhibitor. L-Serine-O-sulfate potassium attenuates the chronic constriction injury (CCI)-induced increases in NO levels, nNOS phosphorylation at Ser847, PKC-dependent GluN1 phosphorylation at Ser896, and the development of mechanical allodynia in mice. L-Serine-O-sulfate potassium can be used for the research of peripheral neuropathy.

For research use only. We do not sell to patients.

L-Serine-O-sulfate potassium Chemical Structure

CAS No. : 17436-02-1

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Purity & Documentation
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Description

In Vivo

L-Serine-O-sulfate potassium (LSOS) (10 nmol; i.t.; twice daily; 4 days) suppresses neuropathic pain-related mechanical allodynia and associated biochemical markers in four-week-old male ICR mice with chronic constriction injury (CCI)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ICR mice (four-week-old male, 20-25 g, challenged with chronic constriction injury of the sciatic nerve)^[1]
Dosage:	10 nmol
Administration:	i.t.; twice daily; 4 days
Result:	Significantly suppressed CCI-induced mechanical allodynia (reduced paw withdrawal frequency), decreased spinal NO levels (measured as nitrate concentration), increased the ratio of phosphorylated nNOS (Ser847) to total nNOS, reduced NADPH-diaphorase-positive cells in the superficial dorsal horn, and attenuated CCI-induced PKC-dependent (Ser896) phosphorylation of GluN1.

Molecular Weight

223.25

Formula

C₃H₆KNO₆S

CAS No.

17436-02-1

Appearance

Solid

SMILES

O=C(O[K])[C@@H](N)COS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 7.5 mg/mL (33.59 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4793 mL	22.3964 mL	44.7928 mL
5 mM	0.8959 mL	4.4793 mL	8.9586 mL
10 mM	0.4479 mL	2.2396 mL	4.4793 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Data Sheet (273 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Choi SR, et al. Astrocyte D-serine modulates the activation of neuronal NOS leading to the development of mechanical allodynia in peripheral neuropathy. Mol Pain. 2019;15:1744806919843046. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.4793 mL	22.3964 mL	44.7928 mL	111.9821 mL
	5 mM	0.8959 mL	4.4793 mL	8.9586 mL	22.3964 mL
	10 mM	0.4479 mL	2.2396 mL	4.4793 mL	11.1982 mL
	15 mM	0.2986 mL	1.4931 mL	2.9862 mL	7.4655 mL
	20 mM	0.2240 mL	1.1198 mL	2.2396 mL	5.5991 mL
	25 mM	0.1792 mL	0.8959 mL	1.7917 mL	4.4793 mL
	30 mM	0.1493 mL	0.7465 mL	1.4931 mL	3.7327 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.