L-Serine-O-sulfate potassium
Based on 1 Customer Validation
L-Serine-O-sulfate potassium is a serine racemase (Srr) inhibitor. L-Serine-O-sulfate potassium attenuates the chronic constriction injury (CCI)-induced increases in NO levels, nNOS phosphorylation at Ser847, PKC-dependent GluN1 phosphorylation at Ser896, and the development of mechanical allodynia in mice. L-Serine-O-sulfate potassium can be used for the research of peripheral neuropathy.
For research use only. We do not sell to patients.
- CAS No.: 17436-02-1
- Formula: C3H6KNO6S
- Molecular Weight:223.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (four-week-old male, 20-25 g, challenged with chronic constriction injury of the sciatic nerve)[1]
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Dosage:10 nmol
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Administration:i.t.; twice daily; 4 days
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Result:Significantly suppressed CCI-induced mechanical allodynia (reduced paw withdrawal frequency), decreased spinal NO levels (measured as nitrate concentration), increased the ratio of phosphorylated nNOS (Ser847) to total nNOS, reduced NADPH-diaphorase-positive cells in the superficial dorsal horn, and attenuated CCI-induced PKC-dependent (Ser896) phosphorylation of GluN1.
Chemical Information
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CAS No. 17436-02-1
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Appearance Solid
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Molecular Weight 223.25
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Formula C3H6KNO6S
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SMILES
O=C(O[K])[C@@H](N)COS(=O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 7.5 mg/mL (33.59 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.4793 mL | 22.3964 mL | 44.7928 mL | 111.9821 mL |
| 5 mM | 0.8959 mL | 4.4793 mL | 8.9586 mL | 22.3964 mL | |
| 10 mM | 0.4479 mL | 2.2396 mL | 4.4793 mL | 11.1982 mL | |
| 15 mM | 0.2986 mL | 1.4931 mL | 2.9862 mL | 7.4655 mL | |
| 20 mM | 0.2240 mL | 1.1198 mL | 2.2396 mL | 5.5991 mL | |
| 25 mM | 0.1792 mL | 0.8959 mL | 1.7917 mL | 4.4793 mL | |
| 30 mM | 0.1493 mL | 0.7465 mL | 1.4931 mL | 3.7327 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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