Phosphatidic acids (PA)

DMPA (1,2-Dimyristoyl-sn-glycero-3-phosphate; 1,2-Dimyristoyl-PA) is a phospholipid that can be used for preparing liposomes. DMPA, when used as a negatively charged lipid component in fluid liposomes, supports liposome-bacterium fusion. DMPA can be used in the research of drug delivery.

16:0-22:6 PA (sodium) is a phosphatidic acid.

17:0 Cyclic LPA ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

22:6 PA sodium is a phosphatidic acid.

C16 Cyclic LPA ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

17:0 Lyso PA sodium is a lysophosphatidic acid.

VPC 51299 is a phosphatidic acid.

1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid containing arachidonic acid at the sn-1 position. It is a precursor to 1-arachidonoyl glycerol (1-Monoarachidin; HY-130567). 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.

1-Stearoyl-sn-glycerol 3-phosphate sodium is a bioactive phospholipid that plays a crucial role in modulating cellular processes such as motility, proliferation, invasion, survival, and growth factor production, primarily through its interaction with G protein-coupled receptors (GPCRs). Typically found at low concentrations in plasma (~100nM), this compound is synthesized during the formation of membrane phospholipids and is derived from various cell types, including activated platelets, epithelial cells, leukocytes, neuronal cells, and tumor cells. Its unique structure includes stearic acid at the sn-1 position alongside a hydroxyl group at the sn-2 position.