Muscarinic M4 modulator-1
Muscarinic M4 modulator-1 is a Muscarinic M4 receptor positive allosteric modulator. Muscarinic M4 modulator-1 activates the muscarinic M4 receptor with allosteric potency EC50 s of 14 and 3 Nm in CHO-K1 cells and HEK293 cells. Muscarinic M4 modulator-1 has an antipsychotic-like activity, promising for psychiatric and/or neurological disorders research.
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- CAS No.: 3082186-91-9
- Formule: C21H22F2N6O
- Masse moléculaire:412.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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mAChR4 |
In Vitro
Muscarinic M4 modulator-1 (Example 4) (0.2-4 h) activates the muscarinic M4 receptor with allosteric potency EC50 s of 14 and 3 nM for Muscarinic M4 receptor in CHO-K1 cells and HEK293 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | Cmax | Tmax | AUC0-t | T1/2 |
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| Rat[1] | 5 mg/kg | i.p. | 1167 ng/mL | 0.25 h | 6135 ng·h/mL | 4.45 h |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats[1].
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Dosage:10, 30 mg/kg
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Administration:i.p., once following administering intravenously with MK-6884 (3 μg/Kg) through lateral tail vein at Tmax.
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Result:Caused 33.9% and 66.7% receptor occupancy at 10 and 30 mg/kg in rats.
Chemical Information
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CAS No. 3082186-91-9
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Masse moléculaire 412.44
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Formule C21H22F2N6O
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SMILES
CC1=CC2=NC(C)=NN2C3=C1CN(C(CC4CN(C5=CC(C(F)F)=NC=C5)C4)=O)C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Muscarinic M4 modulator-1 Related Classifications
HY-174259 Related Classifications
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