Muscarinic M4 modulator-1
Muscarinic M4 modulator-1 is a Muscarinic M4 receptor positive allosteric modulator. Muscarinic M4 modulator-1 activates the muscarinic M4 receptor with allosteric potency EC50 s of 14 and 3 Nm in CHO-K1 cells and HEK293 cells. Muscarinic M4 modulator-1 has an antipsychotic-like activity, promising for psychiatric and/or neurological disorders research.
For research use only. We do not sell to patients.
- CAS No.: 3082186-91-9
- Formula: C21H22F2N6O
- Molecular Weight:412.44
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
mAChR4 |
Muscarinic M4 modulator-1 (Example 4) (0.2-4 h) activates the muscarinic M4 receptor with allosteric potency EC50 s of 14 and 3 nM for Muscarinic M4 receptor in CHO-K1 cells and HEK293 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | Tmax | AUC0-t | T1/2 |
|---|---|---|---|---|---|---|
| Rat[1] | 5 mg/kg | i.p. | 1167 ng/mL | 0.25 h | 6135 ng·h/mL | 4.45 h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Wistar rats[1].
-
Dosage:10, 30 mg/kg
-
Administration:i.p., once following administering intravenously with MK-6884 (3 μg/Kg) through lateral tail vein at Tmax.
-
Result:Caused 33.9% and 66.7% receptor occupancy at 10 and 30 mg/kg in rats.
Chemical Information
-
CAS No. 3082186-91-9
-
Molecular Weight 412.44
-
Formula C21H22F2N6O
-
SMILES
CC1=CC2=NC(C)=NN2C3=C1CN(C(CC4CN(C5=CC(C(F)F)=NC=C5)C4)=O)C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Muscarinic M4 modulator-1 Related Classifications
HY-174259 Related Classifications
Powered by Bioz