2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Nav1.7-IN-15

Nav1.7-IN-15 (Compd 9) is a potent and state-dependent Nav1.7 antagonist, with an IC50 of 0.42 μM for hNav1.7 PX.

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Nav1.7-IN-15

Nav1.7-IN-15 화학구조

CAS No. : 1356834-62-2

사이즈 가격 재고 수량
1 mg 견적 받기 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
5 mg 견적 받기 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
10 mg 견적 받기 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
50 mg   견적 받기  
100 mg   견적 받기  
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고객리뷰

Based on 1 publication(s) in Google Scholar

Nav1.7-IN-15 Related Antibodies

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Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8 Nav1.9

  • Biological Activity

  • 순도&문서

  • References

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제품 설명

Nav1.7-IN-15 (Compd 9) is a potent and state-dependent Nav1.7 antagonist, with an IC50 of 0.42 μM for hNav1.7 PX[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
0.08 μM
Compound: 9
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay
[PMID: 22209205]
HEK293 IC50
0.2 μM
Compound: 9
Antagonist activity at partially inactivated human sodium channel Nav1.5 expressed in human HEK293 cells by patch-clamp electrophysiological assay
Antagonist activity at partially inactivated human sodium channel Nav1.5 expressed in human HEK293 cells by patch-clamp electrophysiological assay
[PMID: 22209205]
HEK293 IC50
0.42 μM
Compound: 9
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay
[PMID: 22209205]
HEK293 IC50
0.5 μM
Compound: 9
Antagonist activity at non-inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay
Antagonist activity at non-inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay
[PMID: 22209205]
분자량

303.42

화학식

C16H21N3OS
CAS No.
SMILES

O=C1N(C)C(SCC2=CC=C(C(C)(C)C)C=C2)=NC(N)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Nav1.7-IN-15 Related Classifications

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  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nav1.7-IN-151356834-62-2Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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상품명:
Nav1.7-IN-15
Cat. No.:
HY-138816
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