2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Nav1.8-IN-4

Nav1.8-IN-4 (compound 9a) is a Nav1.8 channel inhibitor (IC50=0.014 μM). Nav1.8-IN-4 can be used for research on pain-related diseases.

For research use only. We do not sell to patients.

Nav1.8-IN-4 Chemical Structure

Nav1.8-IN-4 Chemical Structure

CAS No. : 1620846-16-3

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5 mg USD 155 In-stock
10 mg USD 250 In-stock
25 mg USD 490 In-stock
50 mg USD 780 In-stock
100 mg USD 1230 In-stock
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Based on 1 publication(s) in Google Scholar

Nav1.8-IN-4 Related Antibodies

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Description

Nav1.8-IN-4 (compound 9a) is a Nav1.8 channel inhibitor (IC50=0.014 μM). Nav1.8-IN-4 can be used for research on pain-related diseases[1].

IC50 & Target

IC50=0.014 μM (Nav1.8)[1].
Molecular Weight

406.33

Formula

C20H14F4N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(NC(C2=CC=C(C(F)(F)F)C=C2OC3=CC=C(C=C3C)F)=O)C=CN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (307.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4611 mL 12.3053 mL 24.6105 mL
5 mM 0.4922 mL 2.4611 mL 4.9221 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4611 mL 12.3053 mL 24.6105 mL 61.5263 mL
5 mM 0.4922 mL 2.4611 mL 4.9221 mL 12.3053 mL
10 mM 0.2461 mL 1.2305 mL 2.4611 mL 6.1526 mL
15 mM 0.1641 mL 0.8204 mL 1.6407 mL 4.1018 mL
20 mM 0.1231 mL 0.6153 mL 1.2305 mL 3.0763 mL
25 mM 0.0984 mL 0.4922 mL 0.9844 mL 2.4611 mL
30 mM 0.0820 mL 0.4102 mL 0.8204 mL 2.0509 mL
40 mM 0.0615 mL 0.3076 mL 0.6153 mL 1.5382 mL
50 mM 0.0492 mL 0.2461 mL 0.4922 mL 1.2305 mL
60 mM 0.0410 mL 0.2051 mL 0.4102 mL 1.0254 mL
80 mM 0.0308 mL 0.1538 mL 0.3076 mL 0.7691 mL
100 mM 0.0246 mL 0.1231 mL 0.2461 mL 0.6153 mL
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Nav1.8-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nav1.8-IN-41620846-16-3Sodium ChannelNa channelsNa+ channelspainInhibitorinhibitorinhibit

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