Nortracheloside

Name: Nortracheloside
Brand: MedChemExpress
SKU: HY-N4276
Rating: 4.5 (0 reviews)

製品番号: HY-N4276 純度: 99.84%: Data Sheet SDS COA 取扱説明書
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Nortracheloside is a lignan isolated from Trachelospermum jasminoides (Lindl.) Lem.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Nortracheloside 構造式

CAS 番号 : 33464-78-7

容量	価格（税別）	在庫状況	数量
5 mg	$300	在庫あり	Estimated Time of Arrival: December 31
10 mg	$480	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

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•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Nortracheloside is a lignan isolated from Trachelospermum jasminoides (Lindl.) Lem^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	0.127 mM Compound: 26	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 18986199]
RAW264.7	IC₅₀	0.127 μM/mL Compound: 26	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 18986199]

分子量

536.53

分子式

C₂₆H₃₂O₁₂

CAS 番号

33464-78-7

Appearance

Solid

Color

White to off-white

SMILES

COC1=C(O)C=CC(C[C@@H]2[C@](O)(C(OC2)=O)CC3=CC(OC)=C(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO)C=C3)=C1

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (232.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8638 mL	9.3191 mL	18.6383 mL
5 mM	0.3728 mL	1.8638 mL	3.7277 mL
10 mM	0.1864 mL	0.9319 mL	1.8638 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 10 mg/mL (18.64 mM); Clear solution

This protocol yields a clear solution of ≥ 10 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (100.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 10 mg/mL (18.64 mM); Clear solution

This protocol yields a clear solution of ≥ 10 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (100.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.84%

Select Batch:

データシート (277 KB) SDS (251 KB)

COA (259 KB) HNMR (275 KB) LCMS (257 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Xing-Qi Tan, et al. Lignans from Trachelospermum jasminoides. Planta Med. 2005 Jan;71(1):93-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8638 mL	9.3191 mL	18.6383 mL	46.5957 mL
	5 mM	0.3728 mL	1.8638 mL	3.7277 mL	9.3191 mL
	10 mM	0.1864 mL	0.9319 mL	1.8638 mL	4.6596 mL
	15 mM	0.1243 mL	0.6213 mL	1.2426 mL	3.1064 mL
	20 mM	0.0932 mL	0.4660 mL	0.9319 mL	2.3298 mL
	25 mM	0.0746 mL	0.3728 mL	0.7455 mL	1.8638 mL
	30 mM	0.0621 mL	0.3106 mL	0.6213 mL	1.5532 mL
	40 mM	0.0466 mL	0.2330 mL	0.4660 mL	1.1649 mL
	50 mM	0.0373 mL	0.1864 mL	0.3728 mL	0.9319 mL
	60 mM	0.0311 mL	0.1553 mL	0.3106 mL	0.7766 mL
	80 mM	0.0233 mL	0.1165 mL	0.2330 mL	0.5824 mL
	100 mM	0.0186 mL	0.0932 mL	0.1864 mL	0.4660 mL