Aptamers
Aptamers are short single-stranded DNA or RNA that can bind to variety of targets, such as proteins, peptides, carbohydrates, and other molecules, by virtue of their tertiary structure, rather than their sequence. The aptamers have a high affinity to target protein similar to antibodies. Compared to antibodies, however, aptamers are small in size and have additional advantages, including improved transport into the cells and lower cost.
M9-5 sodium
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RNA,(GGACCUAUGCAGUAGCCAGUGUGGACUGGGCUGCCCCCCC) sodium salt
製品番号: HY-164186
M9-5 sodium is an aptamer targeting cyclophilin B. M9-5 binds to the MiaPaCa-2 secretory protein with high affinity and can be used as a blood biomarker for the detection of pancreatic cancer.
P12FR2 sodium
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RNA,(5'-GGGCGfUGfCfUGGGfCfCfUGfUAAAfUAfCAfCGfCAfUfCGfUAfUfCfUfCGAfUfUfCGfCAfUfCfCfCfUGAfCfUfCAfUAAfCfCfCAGAGGfUfCGAfUG-3') sodium salt, (All C and U are 2'-fluoro-pyrimidine modified nucleic acids.)
製品番号: HY-164185
P12FR2 sodium is an aptamer targeting human pancreatic adenocarcinoma up-regulated factor (PAUF). P12FR2 specifically binds to human PAUF with an estimated apparent KD of 77 nM. P12FR2 inhibits PAUF-induced PANC-1 cell migration and pancreatic cancer xenograft growth.
2-2(t) aptamer sodium
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DNA, 5'-GCAGCGGTGTGGGGGCAGCGGTGTGGGGGCAGCGGTGTGGGG-3′, sodium salt
製品番号: HY-160068
純度: 99.28%
- 分子量: 13326.62 (free acid)
2-2(t) aptamer sodium is a 42-nucleotide trimeric complex of aptamer (2-2) targeting ErbB-2. 2-2(t) aptamer sodium inhibits the growth of gastric cancer cells in vitro and in vivo.
