Polymers
The utility of polymers to function as intracellular delivery systems for nucleic acids has been studied for several decades. For instance, cationic polymers are able to condense nucleic acids into polyplexes via electrostatic interactions, enhancing cellular uptake and endosome escape. Notably, the physiochemical properties of polymers (charge, degradability and molecular weight) can be carefully adjusted through bottom-up chemical synthesis. Up to now, cyclodextrin polymer (CDP)-based nanoparticles have entered clinical trials for siRNA delivery.
mPEG350-Mal
Cat. No.: HY-W020780A
CAS No.: 724722-89-8
Synonyms: mPEG350-Maleimide
- Molecular Weight: 350 (Average)
mPEG350-Mal is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
Mal-PEG-PLA (PEG MW 3000 & PLA MW 70,000)
Cat. No.: HY-139818
Mal-PEG-PLA (PEG MW 3000 & PLA MW 70,000) is a block copolymer, which can be used to preparenanoparticles and micelles for targeted drug delivery.
Mal-PEG1000-OH
Cat. No.: HY-155902B
CAS No.: 88504-24-9
Synonyms: Maleimide-PEG1000-Hydroxy
- Formula: (C2H4O)nC9H12N2O4
- Molecular Weight: 1000 (Average)
Mal-PEG1000-OH was used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.
