Polymers

mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells.

m-PEG3400-NHS ester (mPEG3400-SC; mPEG3400-Succinimidyl ester) is a polyethylene glycol (PEG)-based biocompatibility-enhancing modifier. m‑PEG3400‑NHS ester enables PEGylation of molecules such as proteins, which reduces the immunogenicity and antigenicity of target molecules, decreases the tendency of protein aggregation, and protects proteins from hydrolysis. m-PEG3400-NHS ester can be used in drug delivery-related research.

Mal-NH-PEG2000-NH2 (Maleimide-NH-PEG2000-amine) TFA is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.

PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is a degradable amphiphilic polymer nanocarrier of poly (lactic acid-co-glycolic acid)-block-poly (ethylene glycol) (PLGA-PEG-Mal) that allows covalent modification of functional molecules. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) serves as a core polymer for nanoparticle synthesis, and also acts as a nanoparticle component for site-specific antibody conjugation to construct artificial antigen-presenting cells. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is applicable for drug delivery-related research.

PEG1000-bis-amine (Poly (ethylene glycol)-bis-amine 1000) is a polyethylene glycol-based diamine linker/spacer. PEG-bis-amine can be used to synthesize CS-PEG-PLGA copolymers, which are further employed to prepare 5-fluorouracil (HY-90006)-loaded nanoparticles. PEG-bis-amine facilitates the formation of amino-terminated PLGA-PEG-NH₂ for conjugation with Chondroitin sulfate (HY-B2162).

m-PEG350-thiol (mPEG350-SH) is a thiol-terminated polyethylene glycol ligand. m-PEG350-thiol participates in thiol-ene/thiol-yne click reactions to graft PEG chains onto hyperbranched and linear polyesters.

PLGA-PEG-MAL (60kDa-3.4kDa, LA:GA ratio 75:25) is a biodegradable amphipathic polymeric nanocarrier of poly (lactic-co-glycolic acid)-block-poly (ethylene glycol) (PLGA-PEG-Mal) that allows covalent modification of functional molecules. PLGA-PEG-MAL (60kDa-3.4kDa, LA:GA ratio 75:25) modified with Angiopep-2 can cross the blood-brain barrier and exhibits targeting selectivity for glioblastoma cells. PLGA-PEG-MAL (60kDa-3.4kDa, LA:GA ratio 75:25) can capture tumor-derived protein antigens, and exerts immunomodulatory effects when conjugated with anti-OX40 antibody; when used in combination with A2-CL/Dbait nanoparticles and radiotherapy, it prolongs survival time and reduces tumor volume in glioblastoma mouse models. PLGA-PEG-MAL (60kDa-3.4kDa, LA:GA ratio 75:25) can be used for studies related to bacterial wound infections and glioblastoma.

Dolichol (13~21) is a lipid carrier containing isoprene units. Dolichol (13~21) can be used for liposomes applied in drug delivery.

mPEG3400-amine (mPEG3400-NH2) is a PEG-based amine. It can be used to synthesize polymer micelles for drug delivery.

mPEG350-amine (mPEG350-NH2) is a PEG-based amine that serves as a precursor for the synthesis of PEG acrylamide macromonomers. mPEG350-amine is used for the synthesis of polymeric micelles for drug delivery.

m-PEG550-NHS ester (mPEG550-SC; mPEG550-Succinimidyl ester) is a polyethylene glycol (PEG)-based biocompatibility-enhancing modifier. m‑PEG550‑NHS ester enables PEGylation of molecules such as proteins, which reduces the immunogenicity and antigenicity of target molecules, decreases the tendency of protein aggregation, and protects proteins from hydrolysis. m-PEG550-NHS ester can be used in drug delivery-related research.

PLGA-PEG-PLGA (hydrogel) (LA:GA 7:1) (15% solution) is a biodegradable thermosensitive hydrogel product that can undergo phase transition at a specific temperature. PLGA-PEG-PLGA (hydrogel) (LA:GA 7:1) (15% solution) can be widely used in drug delivery systems, tissue engineering, wound dressings, and biosensors. The gelation temperature varies with concentration. The gelation temperature varies with the concentration; the higher the concentration, the lower the gelation temperature.

m-PEG3400-thiol modifies DNA thiolation for the synthesis of gold nanorods (AuNRs). Thiolated DNA can be loaded onto AuNR by the mPEG-SH/Tween 20 assisted method (Tween 20 and mPEG-SH repeatedly displace CTAB on the AuNR surface). DNA AuNRs have been widely used in nanostructure assembly, gene therapy, biosensing, and drug delivery.

mPEG20000-CHO participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

mPEG10000-CHO participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

mPEG5000-CHO participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

mPEG2000-CHO participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

mPEG1000-CHO participates in the formation of a three-dimensional porous scaffold that carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

mPEG4000-amine can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

mPEG750-Mal is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.