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Cat. No.: HY-70028

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p53 and MDM2 proteins-interaction-inhibitor (racemic)

p53 and MDM2 proteins-interaction-inhibitor (racemic) (Compound 2j) is an inhibitor of the interaction between p53 and MDM2 proteins.

For research use only. We do not sell to patients.

CAS No.: 939983-14-9
Formula: C₄₀H₄₉Cl₂N₅O₄
Molecular Weight:734.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

p53 and MDM2 proteins-interaction-inhibitor (racemic) Chemical Structure

CAS No.: 939983-14-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

p53 and MDM2 proteins-interaction-inhibitor (racemic) (Compound 2j) is an inhibitor of the interaction between p53 and MDM2 proteins.

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.6 μM Compound: 2k	Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay	[PMID: 24900694]
MDA-MB-435	IC₅₀	17.5 μM Compound: 2k	Cytotoxicity against human MDA-MB-435 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay Cytotoxicity against human MDA-MB-435 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay	[PMID: 24900694]
RKO	IC₅₀	0.6 μM Compound: 2k	Cytotoxicity against human RKO cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay Cytotoxicity against human RKO cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay	[PMID: 24900694]
SJSA-1	IC₅₀	0.2 μM Compound: 2k	Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay	[PMID: 24900694]
SW480	IC₅₀	14.4 μM Compound: 2k	Cytotoxicity against human SW480 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay Cytotoxicity against human SW480 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay	[PMID: 24900694]

Chemical Information

CAS No. 939983-14-9
Molecular Weight 734.76
Formula C₄₀H₄₉Cl₂N₅O₄
SMILES

O=C(N1C(C2=CC=C(C=C2OCC)C(C)(C)C)=N[C@](C)([C@]1(C3=CC=C(Cl)C=C3)C)C4=CC=C(C=C4)Cl)N5CCN(CC5)CC(N6CCOCC6)=O.[relative stereochemistry]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vu B, et al. Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development. ACS Med Chem Lett. 2013 Apr 2;4(5):466-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

p53 and MDM2 proteins-interaction-inhibitor (racemic)

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Biological Activity
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References

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p53 and MDM2 proteins-interaction-inhibitor (racemic)

Biological Activity

Description

Cellular Effect

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

p53 and MDM2 proteins-interaction-inhibitor (racemic) Related Classifications

HY-70028 Related Classifications

Bioz

Keywords

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