PARP1-IN-46
PARP1-IN-46 is a potent PARP-1 inhibitor with an IC50 of 2.4 nM. PARP1-IN-46 demonstrates remarkable anti-proliferative activity in both rat (C6) and human (U87MG) glioma cells. PARP1-IN-46 promotes PARP cleavage, triggers DNA damage, and increases ROS. PARP1-IN-46 effectively inhibits the migration, invasion and colony formation of glioma cells, and ultimately induces cell apoptosis. PARP1-IN-46 can be used to the study of glioma.
For research use only. We do not sell to patients.
- CAS No.: 2505146-00-7
- Formula: C18H11NO4
- Molecular Weight:305.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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PARP-1 2.4 nM (IC50) |
PARP1-IN-46 (Compound 5c) (24 h) demonstrates consistent antiproliferative activity in C6, U87MG, Ovcar-3 and A549 with IC50s of 1.34, 1.28, 4.91 and 1.37 μM[1].
PARP1-IN-46 (24 h-14 d) significantly inhibits the migration, invasion and colony formation of C6 and U87MG cells[1].
PARP1-IN-46 (24 h) significantly increases the proportion of cells undergoing early and late apoptosis C6 and U87MG cells[1].
PARP1-IN-46 (24 h) significantly induces PARP protein cleavage, and upregulates the expression of DNA damage marker γ-H2AX, while downregulating the anti-apoptotic protein Bcl-2 in C6 cells[1].
PARP1-IN-46 (24 h) causes DNA damage and significantly increases the ROS levels in both C6 and U87MG cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2505146-00-7
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Molecular Weight 305.28
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Formula C18H11NO4
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SMILES
O=C(C(C1=CC(OC)=CC=C12)=C3NC2=O)C4=C(C3=O)C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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