Pectic acid
Based on 1 Customer Validation
Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease.
For research use only. We do not sell to patients.
- CAS No.: 9046-40-6
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Pectic acid (2.5-100 μg/mL, 30 min) stimulates the release of prolactin (PRL) in GH3/B6 cells, without affecting the viability of cells[1].
Pectic acid (100 μg/mL-5 mg/mL, 6-48 h) increases cell death and DNA damage in GH3/B6 cells, detected by MTT assay and AO/EB staining[2].
Pectic acid (100 μg/mL-1 mg/mL, 24 h) induces apoptosis in GH3/B6 cells in a dose-dependent manner[2].
Pectic acid (2.5-5 mg/mL, 24 h) induces necrosis in GH3/B6 cells, confirmed by PI staining[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:GH3/B6 cells
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Concentration:1 mg/mL
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Incubation Time:24 h
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Result:Induced sub G1 events, and DNA fragmentation, which was correlated with the number of the apoptotic cells.
Pectic acid (6.25 and 12.5 mg/kg, intravenous injection) rescues the reduction in colon length in UC mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ulcerative colitis (UC) mice[3]
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Dosage:25, 100 mg/kg
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Administration:Oral gavage
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Result:Exhibited the longest colon, lowest DAI, and minimum histopathological score.
Decreased the proinflammatory cytokines in the colonic tissue of UC mice.
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Animal Model:Ulcerative colitis (UC) mice[3]
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Dosage:6.25, 12.5 mg/kg
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Administration:Intravenous injection
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Result:Decreased the spleen and thymus index.
Restored the Th17/Treg balance in the spleen and lamina propria of UC mice.
Improved the gut microbiota composition.
Chemical Information
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CAS No. 9046-40-6
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Appearance Solid
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Color White to off-white
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SMILES
[Pectic acid]
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Synonyms
Methyl protopectin; Polygalacturonic acid
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 20 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Delaram Eslimi, et al. Pectic acid effects on prolactin secretion in GH3/B6 rat pituitary cell line. Iran Biomed J. 2008 Jul;12(3):167-72. [Content Brief]
[2]. Farnoosh Attari, et al. Apoptotic and necrotic effects of pectic acid on rat pituitary GH3/B6 tumor cells. Iran Biomed J. 2009 Oct;13(4):229-36. [Content Brief]
[3]. Jie Song, et al. Effects of oral administration and intravenous injection of polygalacturonic acid on the immunomodulation and gut microbiota in UC mice. Int J Biol Macromol. 2022 Sep 30;217:150-160. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pectic acid Related Classifications
HY-N10520 Related Classifications
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