PF-06456384

Art. -Nr.: HY-118952: Data Sheet Handling Instructions
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PF-06456384 is a highly potent and selective Na_V1.7 inhibitor with an IC₅₀ of 0.01 nM. PF-06456384 has the potential for formalin pain model research.

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PF-06456384 Chemische Struktur

CAS. Nr. : 1834610-73-9

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Other In-stock Forms of PF-06456384:

PF-06456384 trihydrochloride

Other Forms of PF-06456384:

PF-06456384 trihydrochloride In-stock

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Sodium Channel Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8 Na_v1.9

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Kundenbewertung

Beschreibung

PF-06456384 is a highly potent and selective Na_V1.7 inhibitor with an IC₅₀ of 0.01 nM. PF-06456384 has the potential for formalin pain model research^[1].

IC₅₀ & Target^[1]

Na_v1.7

0.01 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.003 μM Compound: 5; PF-06456384	Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assay Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC₅₀	0.0058 μM Compound: 5; PF-06456384	Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assay Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC₅₀	0.075 μM Compound: 5; PF-06456384	Inhibition of rat Nav1.7 expressed in HEK293 cells by electrophysiology assay Inhibition of rat Nav1.7 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC₅₀	0.31 μM Compound: 5; PF-06456384	Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC₅₀	1.5 μM Compound: 5; PF-06456384	Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assay Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC₅₀	2.6 μM Compound: 5; PF-06456384	Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assay Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC₅₀	26 μM Compound: 5; PF-06456384	Inhibition of human Nav1.8 expressed in HEK293 cells by electrophysiology assay Inhibition of human Nav1.8 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC₅₀	6.4 μM Compound: 5; PF-06456384	Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assay Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC₅₀	<0.0001 μM Compound: 5; PF-06456384	Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assay Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC₅₀	<0.1 nM Compound: 5; PF-06456384	Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assay Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]

Molekulargewicht

719.80

Formel

C₃₅H₃₂F₃N₇O₃S₂

CAS. Nr.

1834610-73-9

SMILES

N#CC1=CC(S(=O)(NC2=NC=NS2)=O)=CC=C1OC3=CC=C(C4=CC(C(F)(F)F)=CC=C4)C=C3C5=CC(CNCCC6CCNCC6)=NC=C5

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. R Ian Storer, et al. Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4805-4811. [Content Brief]

PF-06456384 Related Classifications

Neurological Disease

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-064563841834610-73-9PF06456384PF 06456384Sodium ChannelNa channelsNa+ channelsNaV1.7formalin painInhibitorinhibitorinhibit

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