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Cat. No.: HY-181192

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PROTAC SARS-CoV-2 Mpro degrader-6

PROTAC SARS-CoV-2 Mpro degrader-6 is a PROTACs degrader targeting the SARS-CoV-2 main protease (M^pro). PROTAC SARS-CoV-2 Mpro degrader-6 effectively induces the degradation of M^pro and increases K48-linked polyubiquitination of M^pro in HEK293 cells. PROTAC SARS-CoV-2 Mpro degrader-6 can be used in studies related to coronavirus disease 2019 (COVID-19).

For research use only. We do not sell to patients.

CAS No.: 3122394-70-8
Formula: C₃₃H₄₅N₅O₈
Molecular Weight:639.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

PROTAC SARS-CoV-2 Mpro degrader-6 Chemical Structure

CAS No.: 3122394-70-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Cereblon

All PROTACs Isoforms :

In Vitro

PROTAC SARS-CoV-2 Mpro degrader-6 (0-0.03125 μM; 72 h) induces dose-dependent degradation of SARS-CoV-2 M^pro in HEK293 cells expressing Flag-M^pro, with a DC₅₀ of 0.53 μM and a CC₅₀ of 10.07 μM^[1].
PROTAC SARS-CoV-2 Mpro degrader-6 (0.5 μM; 72 h) significantly increases K48-linked polyubiquitination of M^pro in HEK293 cells expressing Flag-Mpro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293 cells stably expressing Flag-M^pro
Concentration:

0-0.03125 μM
Incubation Time:

72 h
Result:

Induced dose-dependent degradation of M^pro with a DC₅₀ value of 0.530 μM and a maximum degradation rate of 86.8%.

Western Blot Analysis^[1]

Cell Line:

HEK293 cells stably expressing Flag-Mpro
Concentration:

0.5 μM
Incubation Time:

72 h
Result:

Caused a significant increase in K48-linked polyubiquitination of Mpro compared to the control.

Chemical Information

CAS No. 3122394-70-8
Molecular Weight 639.74
Formula C₃₃H₄₅N₅O₈
SMILES

COC([C@@H](NC([C@@H](NC(CCCCCNC1=C2C(N(C3CCC(NC3=O)=O)C(C2=CC=C1)=O)=O)=O)C4CCCCC4)=O)C(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guo LN, et al. Integrated computational screen and validation of thalidomide-based PROTACs targeting SARS-CoV-2 main protease. RSC Med Chem. Published online January 13, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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