2. PROTAC Anti-infection
  3. PROTACs SARS-CoV Virus Protease
  4. PROTAC SARS-CoV-2 Mpro degrader-6

PROTAC SARS-CoV-2 Mpro degrader-6 is a PROTACs degrader targeting the SARS-CoV-2 main protease (Mpro). PROTAC SARS-CoV-2 Mpro degrader-6 effectively induces the degradation of Mpro and increases K48-linked polyubiquitination of Mpro in HEK293 cells. PROTAC SARS-CoV-2 Mpro degrader-6 can be used in studies related to coronavirus disease 2019 (COVID-19).

For research use only. We do not sell to patients.

PROTAC SARS-CoV-2 Mpro degrader-6

PROTAC SARS-CoV-2 Mpro degrader-6 Chemical Structure

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PROTAC SARS-CoV-2 Mpro degrader-6 Related Antibodies

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Description

PROTAC SARS-CoV-2 Mpro degrader-6 is a PROTACs degrader targeting the SARS-CoV-2 main protease (Mpro). PROTAC SARS-CoV-2 Mpro degrader-6 effectively induces the degradation of Mpro and increases K48-linked polyubiquitination of Mpro in HEK293 cells. PROTAC SARS-CoV-2 Mpro degrader-6 can be used in studies related to coronavirus disease 2019 (COVID-19)[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTAC SARS-CoV-2 Mpro degrader-6 (0-0.03125 μM; 72 h) induces dose-dependent degradation of SARS-CoV-2 Mpro in HEK293 cells expressing Flag-Mpro, with a DC50 of 0.53 μM and a CC50 of 10.07 μM[1].
PROTAC SARS-CoV-2 Mpro degrader-6 (0.5 μM; 72 h) significantly increases K48-linked polyubiquitination of Mpro in HEK293 cells expressing Flag-Mpro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC SARS-CoV-2 Mpro degrader-6 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293 cells stably expressing Flag-Mpro
Concentration: 0-0.03125 μM
Incubation Time: 72 h
Result: Induced dose-dependent degradation of Mpro with a DC50 value of 0.530 μM and a maximum degradation rate of 86.8%.

Western Blot Analysis[1]

Cell Line: HEK293 cells stably expressing Flag-Mpro
Concentration: 0.5 μM
Incubation Time: 72 h
Result: Caused a significant increase in K48-linked polyubiquitination of Mpro compared to the control.
Molecular Weight

639.74

Formula

C33H45N5O8
SMILES

COC([C@@H](NC([C@@H](NC(CCCCCNC1=C2C(N(C3CCC(NC3=O)=O)C(C2=CC=C1)=O)=O)=O)C4CCCCC4)=O)C(C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SARS-CoV-2 Mpro degrader-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SARS-CoV-2 Mpro degrader-6PROTACsSARS-CoVVirus ProteaseSARS coronavirusSARS-CoV-2 Mpro DegraderHEK293 cellsCOVID-19Inhibitorinhibitorinhibit

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