Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397)

  • J Med Chem. 1999 Dec 16;42(25):5061-3. doi: 10.1021/jm990517p.
H Kawamoto  1 ,  S Ozaki ,  Y Itoh ,  M Miyaji ,  S Arai ,  H Nakashima ,  T Kato ,  H Ohta ,  Y Iwasawa
Affiliations
  • 1. Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.
PMID: 10602690 DOI: 10.1021/jm990517p