Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues

  • Bioorg Med Chem Lett. 2000 Jul 17;10(14):1519-22. doi: 10.1016/s0960-894x(00)00273-0.
M A deLong  1 ,  J Amburgey ,  C Taylor ,  J A Wos ,  D L Soper ,  Y Wang ,  R Hicks
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PMID: 10915040 DOI: 10.1016/s0960-894x(00)00273-0
Abstract

The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chain aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF2alpha.

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