5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

  • Bioorg Med Chem Lett. 2003 May 5;13(9):1577-80. doi: 10.1016/s0960-894x(03)00134-3.
Jason Witherington  1 ,  Vincent Bordas ,  Stephen L Garland ,  Deirdre M B Hickey ,  Robert J Ife ,  John Liddle ,  Martin Saunders ,  David G Smith ,  Robert W Ward
Affiliations
  • 1. Department of Medicinal Chemistry, Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. [email protected]
PMID: 12699759 DOI: 10.1016/s0960-894x(03)00134-3
Abstract

A novel series of pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Products