Production of new anthracycline antibiotics 1-hydroxy-oxaunomycin and 6-deoxyoxaunomycin by limited biosynthetic conversion using a daunorubicin-negative mutant

  • J Antibiot (Tokyo). 1992 Oct;45(10):1609-17. doi: 10.7164/antibiotics.45.1609.
A Yoshimoto  1 ,  O Johdo ,  H Tone ,  R Okamoto ,  H Naganawa ,  T Sawa ,  T Takeuchi
Affiliations
  • 1. Central Research Laboratory, Mercian Corporation, Kanagawa, Japan.
PMID: 1473988 DOI: 10.7164/antibiotics.45.1609
Abstract

A limited biosynthetic conversion of some known anthracyclinones using a specific daunorubicin-nonproducing mutant provided four new anthracycline antibiotics: 1-Hydroxy-10-methoxycarbonyl-13-deoxocarminomycin; 1-hydroxy-13-deoxocarminomycin; 1-hydroxyoxaunomycin and 6-deoxyoxaunomycin. Their isolation and purification from bioconversion broth, structural determination and antitumor activities against leukemic L1210 cells are described.

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