The cytosolic ribonuclease inhibitor contributes to intracellular redox homeostasis

  • FEBS Lett. 2007 Mar 6;581(5):930-4. doi: 10.1016/j.febslet.2007.01.072.
Daria Maria Monti  1 ,  Nicola Montesano Gesualdi ,  Josef Matousek ,  Franca Esposito ,  Giuseppe D'Alessio
Affiliations
  • 1. Department of Structural and Functional Biology, University of Naples Federico II, Complesso Universitario M.S.Angelo, via Cinthia, 80126, Naples, Italy.
PMID: 17292889 DOI: 10.1016/j.febslet.2007.01.072
Abstract

The hypothesis that the cytosolic RNase Inhibitor (cRI) has a role in the protection of the cellular redox homeostasis was investigated testing the effects of oxidants and anti-oxidants on normal, primary endothelial HUVE cells, and malignant HeLa cells, before and after their engineering into cRI-deprived cells. We found that cRI plays an important, possibly a key, physiological role in the protection of cells from redox stress, as demonstrated by decreased GSH levels as well as increased oxidant-induced DNA damage in cRI deprived cells.