The isolation, structure determination and cytotoxicity of the new fungal metabolite, trichodermamide C

  • Bioorg Med Chem Lett. 2008 May 1;18(9):2836-9. doi: 10.1016/j.bmcl.2008.03.090.
Rohan A Davis  1 ,  James Longden ,  Vicky M Avery ,  Peter C Healy
Affiliations
  • 1. Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Qld 4111, Australia. [email protected]
PMID: 18424045 DOI: 10.1016/j.bmcl.2008.03.090
Abstract

Chemical investigations of a culture broth from the endophytic fungus Eupenicillium sp. afforded the new modified dipeptide trichodermamide C 1. The structure of 1 was established following the analysis of NMR, UV, IR, MS and X-ray diffraction data. Trichodermamide C was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC(50) values of 0.68 and 4.28microg/ml, respectively.

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