Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones

  • Bioorg Med Chem. 2009 Feb 15;17(4):1422-7. doi: 10.1016/j.bmc.2009.01.028.
Thorsten Laube  1 ,  Andreas Bernet ,  Hans-Martin Dahse ,  Ilse D Jacobsen ,  Karlheinz Seifert
Affiliations
  • 1. Lehrstuhl für Organische Chemie, NW II, Universität Bayreuth, Bayreuth, Germany.
PMID: 19188072 DOI: 10.1016/j.bmc.2009.01.028
Abstract

Synthesis of protected siphonodictyal C was achieved via drim-7-en-11-al. Some sesquiterpene Quinones and hydroquinones were tested for their pharmacological activities in assays in search of antiproliferative, cytotoxic, antiphlogistic, antirheumatic and anti-inflammatory drugs. Wiedendiol B is a ten times stronger cyclooxygenase-2 inhibitor than the reference compound indomethacine. Cyclooxygenase-2 inhibitors are drugs with antiphlogistic and antirheumatic activity.