Regulation of translation initiation in eukaryotes: mechanisms and biological targets

  • Cell. 2009 Feb 20;136(4):731-45. doi: 10.1016/j.cell.2009.01.042.
Nahum Sonenberg  1 ,  Alan G Hinnebusch
Affiliations
  • 1. Department of Biochemistry and Goodman Cancer Centre, McGill University, Montreal, Quebec, H3G 1Y6, Canada. [email protected]
PMID: 19239892 DOI: 10.1016/j.cell.2009.01.042
Abstract

Translational control in eukaryotic cells is critical for gene regulation during nutrient deprivation and stress, development and differentiation, nervous system function, aging, and disease. We describe recent advances in our understanding of the molecular structures and biochemical functions of the translation initiation machinery and summarize key strategies that mediate general or gene-specific translational control, particularly in mammalian systems.