Indole alkaloids from Aspidosperma rigidum and A. schultesii and their antiparasitic effects

  • Z Naturforsch C J Biosci. 2011 May-Jun;66(5-6):225-34. doi: 10.1515/znc-2011-5-605.
Matías Reina  1 ,  Wilfredo Ruiz-Mesia ,  Lastenia Ruiz-Mesia ,  Rafael Martínez-Díaz ,  Azucena González-Coloma
Affiliations
  • 1. Instituto de Productos Naturales y Agrobiología (IPNA), CSIC, Avda. Astrofísico F, Sánchez 3, P. O. Box 195, 38206 - La Laguna, Tenerife, Canary Islands, Spain. [email protected]
PMID: 21812339 DOI: 10.1515/znc-2011-5-605
Abstract

Five Oxindole Alkaloids, three plumerane-type Alkaloids, subtype haplophitine, and one aspidospermatane-type alkaloid, subtype tubotaiwine, were isolated from the medicinal Plants Aspidosperma rigidum and A. schultesii. One compound was identified as the transoid conformer of 18-oxo-O-methylaspidoalbine which was not previously described. The antiparasitic activity of all compounds against Trypanosoma cruzi and Leishmania infantum and their non-specific cytotoxicity against mammalian cells were also determined.

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