The discovery of AZD9164, a novel muscarinic M3 antagonist

  • Bioorg Med Chem Lett. 2011 Dec 15;21(24):7440-6. doi: 10.1016/j.bmcl.2011.10.002.
Antonio Mete  1 ,  Keith Bowers ,  Eric Chevalier ,  David K Donald ,  Helen Edwards ,  Katherine J Escott ,  Rhonan Ford ,  Ken Grime ,  Ian Millichip ,  Barry Teobald ,  Vince Russell
Affiliations
  • 1. Department of Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK. [email protected]
PMID: 22047691 DOI: 10.1016/j.bmcl.2011.10.002
Abstract

The optimization of a new series of muscarinic M(3) antagonists is described, leading to the identification of AZD9164 which was progressed into the clinic for evaluation of its potential as a treatment for COPD.

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