Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

  • Medchemcomm. 2013 Apr 1;2013(4):693-696. doi: 10.1039/C3MD00068K.
Sebastian Trousil  #  1 ,  Laurence Carroll  #  1 ,  Andrew Kalusa  1 ,  Ola Aberg  1 ,  Maciej Kaliszczak  1 ,  Eric O Aboagye  1
Affiliations
  • 1. Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, UK.
  • # Contributed equally.
PMID: 24976941 DOI: 10.1039/C3MD00068K
Abstract

Choline Kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising Cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.