Two new phenolic glucosides from Lagerstroemia speciosa

  • Molecules. 2015 Mar 10;20(3):4483-91. doi: 10.3390/molecules20034483.
Janggyoo Choi  1 ,  Jae Youl Cho  2 ,  Soo Jung Choi  3 ,  Heejin Jeon  4 ,  Young Dong Kim  5 ,  Khin Myo Htwe  6 ,  Young Won Chin  7 ,  Woo Shin Lee  8 ,  Jinwoong Kim  1 ,  Kee Dong Yoon  9
Affiliations
  • 1. College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea. [email protected].
  • 2. Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea. [email protected].
  • 3. College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. [email protected].
  • 4. College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. [email protected].
  • 5. Department of Life Science, Hallym University, Chuncheon 200-702, Korea. [email protected].
  • 6. Popa mountain park, Forest Department, Kyaukpadaung Township, Mandalay Division, Myanmar. [email protected].
  • 7. College of Pharmacy and RFIND-BKplus Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsan dong-gu, Goyang 410-820, Korea. [email protected].
  • 8. Department of Forest Sciences, Seoul National University, Seoul 151-921, Korea. [email protected].
  • 9. College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. [email protected].
PMID: 25764490 DOI: 10.3390/molecules20034483
Abstract

Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-d-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-d-glucopyranoside, were isolated from the aerial parts of Lagerstroemia speciosa, along with ten known compounds. The structures of the isolated compounds were determined based on 1D- and 2D-NMR, Q-TOF MS and optical rotation spectroscopic data. All of the compounds showed moderate inhibitory activities against nitric oxide production in lipopolysaccharide-treated RAW264.7 cells, with IC50 values of 69.5-83.3 μM.

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