A concise formal total synthesis of lactimidomycin

  • Chem Commun (Camb). 2015 May 21;51(41):8634-6. doi: 10.1039/c5cc02571k.
Wei Li  1 ,  Gunda I Georg
Affiliations
  • 1. Department of Chemistry, Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414, USA. [email protected].
PMID: 25900419 DOI: 10.1039/c5cc02571k
Abstract

A formal total synthesis of the cytotoxic natural product lactimidomycin has been achieved in nine steps from (E)-2-methyl-2-pentenoic acid. The 12-membered lactone was efficiently formed via a copper-catalyzed ene-yne coupling/alkyne reduction tandem reaction.

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