Officinalioside, a new lignan glucoside from Borago officinalis L

  • Nat Prod Res. 2016;30(8):967-72. doi: 10.1080/14786419.2015.1088540.
Mamdouh Nabil Samy  1  2 ,  Ashraf Nageeb El-Sayed Hamed  2 ,  Sachiko Sugimoto  1 ,  Hideaki Otsuka  3 ,  Mohamed Salah Kamel  2 ,  Katsuyoshi Matsunami  1
Affiliations
  • 1. a Department of Pharmacognosy, Graduate School of Biomedical & Health Sciences , Hiroshima University , Hiroshima , Japan.
  • 2. b Faculty of Pharmacy, Department of Pharmacognosy , Minia University , Minia , Egypt.
  • 3. c Faculty of Pharmacy, Department of Natural Product Chemistry , Yasuda Women's University , Hiroshima , Japan.
PMID: 26382913 DOI: 10.1080/14786419.2015.1088540
Abstract

A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O-β-D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses. Compounds 1 and 2 showed a moderate DPPH radical scavenging activity (IC50: 52.6 ± 1.70 and 41.3 ± 0.25 μM, respectively) comparable with that of the standard trolox (16.6 ± 2.2 μM) without any significant cytotoxicity towards human cell line A549 (IC50 > 100 μM).

Keywords
Boraginaceae; Borago officinalis; DPPH; cytotoxicity; lignan; officinalioside.
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