A new phenylethanoid glycoside from Incarvillea compacta

  • J Asian Nat Prod Res. 2016 Jun;18(6):596-602. doi: 10.1080/10286020.2015.1096931.
Hai-Feng Wu  1 ,  Yin-Di Zhu  1 ,  Li-Jing Zhang  1 ,  Qiong-Yu Zou  2 ,  Li Chen  1  2 ,  Ting Shen  3 ,  Xin-Feng Wang  3 ,  Guo-Xu Ma  1 ,  Bo-Ran Hu  4 ,  Wei-Cheng Hu  3 ,  Xu-Dong Xu  1
Affiliations
  • 1. a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development , Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100193 , China.
  • 2. b Key Laboratory of Hunan Province for Study and Utilization of Ethnic Medicinal Plant Resources, Department of Chemistry & Chemical Engineering , Huaihua University , Huaihua 418008 , China.
  • 3. c Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection/Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake , Huaiyin Normal University , Huaian , China.
  • 4. d College of Food Science and Engineering , Yangzhou University , Yangzhou 225001 , China.
PMID: 26630368 DOI: 10.1080/10286020.2015.1096931
Abstract

A new phenylethanoid glycoside, 3'''-O-methylcampneoside I (1), was isolated from the 90% ethanolic extract of the roots of Incarvillea compacta, together with three known compounds, campneoside I (2), ilicifolioside A (3), and campneoside II (4). Their structures were determined spectroscopically and compared with previously reported spectral data. Compound 1 existed as epimers and displayed better 1,1-diphenyl-2-picrylhydrazyl (DPPH)-free radical scavenging activity using di-tert-butyl-4-methylphenol (BHT) as the positive control. In addition, pretreatment of human HepG2 cells with compound 1 significantly increased the viability on CCl4-induced cell death.

Keywords
3′′′-O-methylcampneoside I; Bignoniaceae; Incarvillea compacta; antioxidant activity; hepatoprotective effect; phenylethanoid glycoside.
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