Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties

  • J Nat Prod. 2016 Jul 22;79(7):1808-14. doi: 10.1021/acs.jnatprod.6b00274.
Komei Kato  1  2 ,  Masayuki Ninomiya  1  2 ,  Kaori Tanaka  1  2 ,  Mamoru Koketsu  1  2
Affiliations
  • 1. Department of Materials Science and Technology and ‡Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University , 1-1 Yanagido, Gifu 501-1193, Japan.
  • 2. Division of Anaerobe Research, Life Science Research Center, and ⊥United Graduate School of Drug Discovery and Medicinal Information Sciences, Gifu University , 1-1 Yanagido, Gifu 501-1194, Japan.
PMID: 27314621 DOI: 10.1021/acs.jnatprod.6b00274
Abstract

Quercetin derivatives are widespread in the plant kingdom and exhibit various biological actions. The aim of this study was to investigate the structure-activity relationships of quercetin derivatives, with a focus on the influence of functional groups and sugar composition on their antioxidant capacity. A series of quercetin derivatives were therefore prepared and assessed for their DPPH radical scavenging properties. Isoquercetin O-gallates were more potent radical scavengers than quercetin. The systematic analysis highlights the importance of the distribution of hydroxy substituents in isoquercetin O-gallates to their potency.

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