Triterpenoids and sterols from the grains of Echinochloa utilis Ohwi & Yabuno and their cytotoxic activity

  • Biomed Pharmacother. 2017 Sep;93:202-207. doi: 10.1016/j.biopha.2017.06.042.
Thi Trang Nguyen  1 ,  Duc Hung Nguyen  2 ,  Bing Tian Zhao  3 ,  Duc Dat Le  3 ,  Byung Sun Min  3 ,  Young Ho Kim  4 ,  Mi Hee Woo  5
Affiliations
  • 1. College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea; Buon Ma Thuot University, Buon Ma Thuot City, Dak Lak Province 630000, Viet Nam.
  • 2. College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea; Phutho College of Medicine and Pharmacy, Viettri City, Phutho Province 290000, Viet Nam.
  • 3. College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea.
  • 4. Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 39061, Republic of Korea.
  • 5. College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea. Electronic address: [email protected].
PMID: 28641162 DOI: 10.1016/j.biopha.2017.06.042
Abstract

Two new Tetracyclic Triterpenoids, echinochlorins C (1) and D (2), and sawamilletin (3) with new spectroscopic data were isolated from Echinochloa utilis Ohwi & Yabuno grains, along with one known triterpenoid (4) and eight sterols (5-12). Their structures were elucidated by spectroscopic data analyses (IR, UV, MS, and NMR). These compounds were tested in vitro cytotoxic activities against the human tumor-cell lines (HeLa, HL-60, and MCF-7). Compounds 6 and 8 displayed potential cytotoxic activity against HeLa, with IC50 values of 3.1±0.9 and 3.2±0.8μM, respectively. This finding indicated that Tetracyclic Triterpenoids isolated from E. utilis may have potential beneficial effects for the treatment of Cancer.

Keywords
Cytotoxic activity; Echinochloa utilis; Echinochlorins C and D; Sawamilletin.
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