Cytotoxic Dibohemamines D-F from a Streptomyces Species

  • J Nat Prod. 2017 Oct 27;80(10):2825-2829. doi: 10.1021/acs.jnatprod.7b00136.
Bingya Jiang  1 ,  Wei Zhao  1 ,  Shufen Li  1 ,  Hongyu Liu  1 ,  Liyan Yu  1 ,  Yixuan Zhang  1 ,  Hongwei He  1 ,  Linzhuan Wu  1
Affiliations
  • 1. Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
PMID: 29035560 DOI: 10.1021/acs.jnatprod.7b00136
Abstract

Three dimeric analogues of bohemamines, dibohemamines D-F (1-3), together with dibohemamine A (4), were isolated from Streptomyces sp. CPCC 200497. Their structures were solved using a combination of mass spectrometry, 1D and 2D NMR spectroscopy, and CD. Dibohemamines D and E were new dimeric analogues of bohemamines, and dibohemamine F was a known compound obtained previously by semisynthesis. Dibohemamine F displayed potent cytotoxicity against Cancer cell lines A549 and HepG2 with IC50 values of 1.1 and 0.3 μM, respectively. Dibohemamines D and E showed moderate cytotoxicity against Cancer cell lines A549 and HepG2.