Antimutagenic activity of flavonoids from Sozuku

  • Nat Prod Res. 2019 Mar;33(6):862-865. doi: 10.1080/14786419.2017.1408104.
Yoshiharu Okuno  1 ,  Shinsuke Marumoto  2 ,  Mitsuo Miyazawa  3  4  5
Affiliations
  • 1. a Department of Applied Chemistry and Biochemistry , National Institute of Technology, Wakayama Collage , Gobo-shi , Japan.
  • 2. b Joint Research Centre , Kindai University (Former name: Kinki University) , Higashiosaka-shi , Japan.
  • 3. c Graduate School of Materials Science , Nara Institute of Science and Technology , Ikoma , Japan.
  • 4. d Department of Applied Chemistry , Kindai University (Former name: Kinki University) , Higashiosaka-shi , Japan.
  • 5. e Graduate School of Science , Osaka City University , Osaka-shi , Japan.
PMID: 29183163 DOI: 10.1080/14786419.2017.1408104
Abstract

Pinocembrin (1) and cardamonin (2) from Sozuku showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen furylfuramide. Compounds 1 and 2 suppressed 52% and 36% of SOS-inducing activity at a concentration of 0.20 μmol/mL. The ID50 value of 1 was 0.18 μmol/mL. These compounds showed the suppression of 2-amino-3,4-dimethylimidazo-[4,5-f]Quinolone (MeIQ) and UV irradiation-induced SOS response. Pinostrobin (3) and 5,7-dimethoxyflavanone (4), methyl ethers of 1, showed similar activity to 1 against MeIQ-induced SOS response, but that of furylfuramide and UV irradiation were decreased. On the Other hand, compounds 1-4 did not show the suppression of activated MeIQ-induced SOS response. Furthermore, compounds 1-4 showed potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains.

Keywords
Hayata; test; Ames test; Sozuku; antimutagenic activity; cardamonin; pinocembrin.
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