Phenylpropanoid-Conjugated Triterpenoids from the Leaves of Actinidia arguta and Their Inhibitory Activity on α-Glucosidase

  • J Nat Prod. 2020 May 22;83(5):1416-1423. doi: 10.1021/acs.jnatprod.9b00643.
Jong Hoon Ahn  1 ,  Youngki Park  2 ,  Sang Won Yeon  1 ,  Yang Hee Jo  1 ,  Yoo Kyong Han  3 ,  Ayman Turk  1 ,  Se Hwan Ryu  1 ,  Bang Yeon Hwang  1 ,  Ki Yong Lee  3 ,  Mi Kyeong Lee  1
Affiliations
  • 1. College of Pharmacy, Chungbuk National University, Cheongju 28160, Korea.
  • 2. Division of Special Purpose Trees, National Institute of Forest Science, Suwon 16631, Korea.
  • 3. College of Pharmacy, Korea University, Sejong 47236, Korea.
PMID: 32315181 DOI: 10.1021/acs.jnatprod.9b00643
Abstract

Actinidia arguta, commonly called hardy kiwifruit or kiwiberry, has cold-resistant properties and can be cultivated in Asia, including Korea. Seven new triterpenoids (2-4 and 8-11) along with eight known triterpenoids were isolated from the leaves of A. arguta through various chromatographic techniques. The new triterpenoids were defined as actiniargupenes A-C (2-4), actinidic acid derivatives with phenylpropanoid constituent units, dehydroisoactinidic acid (8), and actiniargupenes D-F (9-11), asiatic acid derivatives with phenylpropanoid substituents, on the basis of 1D and 2D NMR and MS data. Among the triterpenoids, those with a phenylpropanoid constituent unit showed inhibitory activity on α-glucosidase, which suggested the importance of the phenylpropanoid moiety. Molecular docking analysis demonstrated the interaction between the 4'-OH group of the phenylpropanoid moiety and α-glucosidase.

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