DEF6 deficiency, a mendelian susceptibility to EBV infection, lymphoma, and autoimmunity PMID: 32562707

RQC and Longevity Regulation

2026-09-03

DEF6 deficiency, a mendelian susceptibility to EBV infection, lymphoma, and autoimmunity

J Allergy Clin Immunol. 2021 Feb;147(2):740-743.e9. doi: 10.1016/j.jaci.2020.05.052.

Benjamin Fournier ¹ , Maud Tusseau ² , Marine Villard ³ , Christophe Malcus ⁴ , Emilie Chopin ⁵ , Emmanuel Martin ¹ , Debora Jorge Cordeiro ¹ , Nicole Fabien ³ , Mathieu Fusaro ⁶ , Alexandra Gauthier ⁷ , Nathalie Garnier ⁷ , David Goncalves ³ , Sonia Lounis ¹ , Christelle Lenoir ¹ , Anne-Laure Mathieu ² , Marion Moreews ² , Magali Perret ³ , Capucine Picard ⁸ , Cécile Picard ⁹ , Françoise Poitevin ⁴ , Sébastien Viel ¹⁰ , Yves Bertrand ¹¹ , Thierry Walzer ² , Alexandre Belot ¹² , Sylvain Latour ¹³

Affiliations

1. Laboratory of Lymphocyte Activation and Susceptibility to EBV infection, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR 1163, F-75015, Paris, France; Université de Paris, Imagine Institute, F-75015, Paris, France.
2. International Center for Infectiology Research, Inserm U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, CNRS, UMR5308, Lyon, France.
3. Immunology Department, Centre Hospitalier Lyon Sud, Pierre-Bénite, Lyon 1 University, France.
4. Immunology Laboratory, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
5. Centre de Biotechnologie Cellulaire, Centre de Biologie et Pathologie Est, Hospices Civils de Lyon, Bron, France.
6. Laboratory of Lymphocyte Activation and Susceptibility to EBV infection, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR 1163, F-75015, Paris, France; Study Center for Primary Immunodeficiencies, Assistance Publique Hôpitaux de Paris, Necker-Enfants Malades Hospital, F-75015, Paris, France.
7. Institut d'Hématologie et d'Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France.
8. Laboratory of Lymphocyte Activation and Susceptibility to EBV infection, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR 1163, F-75015, Paris, France; Université de Paris, Imagine Institute, F-75015, Paris, France; Study Center for Primary Immunodeficiencies, Assistance Publique Hôpitaux de Paris, Necker-Enfants Malades Hospital, F-75015, Paris, France.
9. Institut de Pathologie Multisite, Groupement Hospitalier Est, Hospices Civils de Lyon, UCBL Lyon 1 University, Lyon, France.
10. International Center for Infectiology Research, Inserm U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, CNRS, UMR5308, Lyon, France; Immunology Department, Centre Hospitalier Lyon Sud, Pierre-Bénite, Lyon 1 University, France.
11. International Center for Infectiology Research, Inserm U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, CNRS, UMR5308, Lyon, France; Institut d'Hématologie et d'Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France.
12. International Center for Infectiology Research, Inserm U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, CNRS, UMR5308, Lyon, France; National Referee Centre for Rheumatic and AutoImmune and Systemic diseases in childrEn (RAISE), France; Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, University Lyon I, Lyon, France. Electronic address: [email protected].
13. Laboratory of Lymphocyte Activation and Susceptibility to EBV infection, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR 1163, F-75015, Paris, France; Université de Paris, Imagine Institute, F-75015, Paris, France. Electronic address: [email protected].