Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer
- Nat Rev Cardiol. 2022 Jun;19(6):414-425. doi: 10.1038/s41569-022-00698-6.
- 1. Department of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
- 2. Section of Cardio-Oncology & Immunology, Division of Cardiology and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA. [email protected].
- 3. Department of Cardiology, University Medical Center Groningen, Groningen, Netherlands. [email protected].
Cardiovascular Disease and Cancer are the two leading causes of morbidity and mortality in the world. The emerging field of cardio-oncology has revealed that these seemingly disparate disease processes are intertwined, owing to the cardiovascular sequelae of Anticancer therapies, shared risk factors that predispose individuals to both Cardiovascular Disease and Cancer, as well the possible potentiation of Cancer growth by cardiac dysfunction. As a result, interest has increased in understanding the fundamental biological mechanisms that are central to the relationship between Cardiovascular Disease and Cancer. Metabolism, appropriate regulation of energy, energy substrate utilization, and macromolecular synthesis and breakdown are fundamental processes for cellular and organismal survival. In this Review, we explore the emerging data identifying metabolic dysregulation as an important theme in cardio-oncology. We discuss the growing recognition of metabolic reprogramming in Cardiovascular Disease and Cancer and view the novel area of cardio-oncology through the lens of metabolism.