Isolation and characterization of antibiotic X-14547A, a novel monocarboxylic acid ionophore produced by Streptomyces antibioticus NRRL 8167

  • J Antibiot (Tokyo). 1979 Feb;32(2):100-7. doi: 10.7164/antibiotics.32.100.
J W Westley ,  R H Evans Jr ,  L H Sello ,  N Troupe ,  C M Liu ,  J F Blount
PMID: 374323 DOI: 10.7164/antibiotics.32.100
Abstract

A novel carboxylic acid ionophore, Antibiotic X-14547A, closely related to the Polyether Antibiotics has been isolated along with four Other metabolites from fermented cultures of a new strain of Streptomyces antibioticus. The structure, determined by X-ray analysis of the R(+)-1-amino-1-(4-bromophenyl)-ethane salt contained pyrrole carbonyl and trans-butadienyl chromophores in addition to the unusual tetrahydroindane bicyclic ring system. A second novel metabolite was identified as 3-ethyl-1,3-dihydro-3-methoxy-2H-indol-2-one.

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