δ-Opioid Receptor as a Molecular Target for Increasing Cardiac Resistance to Reperfusion in Drug Development

  • Biomedicines. 2023 Jul 3;11(7):1887. doi: 10.3390/biomedicines11071887.
Natalia V Naryzhnaya  1 ,  Alexander V Mukhomedzyanov  1 ,  Maria Sirotina  1 ,  Leonid N Maslov  1 ,  Boris K Kurbatov  1 ,  Alexander S Gorbunov  1 ,  Mikhail Kilin  1 ,  Artur Kan  1 ,  Andrey V Krylatov  1 ,  Yuri K Podoksenov  1 ,  Sergey V Logvinov  2
Affiliations
  • 1. Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk 634021, Russia.
  • 2. Department of Histology, Embryology and Cytology, Siberian State Medical University, Tomsk 634050, Russia.
PMID: 37509526 DOI: 10.3390/biomedicines11071887
Abstract

An analysis of published data and the results of our own studies reveal that the activation of a peripheral δ2-opioid receptor (δ2-OR) increases the cardiac tolerance to reperfusion. It has been found that this δ2-OR is localized in cardiomyocytes. Endogenous opioids are not involved in the regulation of cardiac resistance to reperfusion. The infarct-limiting effect of the δ2-OR agonist deltorphin II depends on the activation of several protein Kinases, including PKCδ, ERK1/2, PI3K, and PKG. Hypothetical end-effectors of the cardioprotective effect of deltorphin II are the sarcolemmal KATP channels and the MPT pore.

Keywords
KATP channels; MPT pore; heart; kinases; myocardial infarction; opioid receptors; reperfusion.