Functions of RNA-Binding Proteins in Cardiovascular Disease

  • Cells. 2023 Dec 8;12(24):2794. doi: 10.3390/cells12242794.
Grégoire Ruffenach  1 ,  Lejla Medzikovic  1 ,  Wasila Sun  1 ,  Jason Hong  2 ,  Mansoureh Eghbali  1
Affiliations
  • 1. Department of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  • 2. Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
PMID: 38132114 DOI: 10.3390/cells12242794
Abstract

Gene expression is under tight regulation from the chromatin structure that regulates gene accessibility by the transcription machinery to protein degradation. At the transcript level, this regulation falls on RNA-binding proteins (RBPs). RBPs are a large and diverse class of proteins involved in all aspects of a transcript's lifecycle: splicing and maturation, localization, stability, and translation. In the past few years, our understanding of the role of RBPs in cardiovascular diseases has expanded. Here, we discuss the general structure and function of RBPs and the latest discoveries of their role in pulmonary and systemic cardiovascular diseases.

Keywords
RNA binding protein; cardiovascular diseases; pathogenesis.