Doramectin attenuates inflammation, obesity and insulin resistance in food-borne obese mice

  • Biochem Biophys Res Commun. 2024 Jul 14:732:150404. doi: 10.1016/j.bbrc.2024.150404.
Tianrong Jin  1 ,  Jialin Jia  2 ,  Wenhua Li  2 ,  Pengfei Wu  3 ,  Tingting Liu  2 ,  Bangwei Luo  4 ,  Zhiren Zhang  5
Affiliations
  • 1. Medical College of Chongqing University, 131 Yubei Road, Shapingba District, Chongqing, 400030, China.
  • 2. Institute of Immunology, Third Military Medical University, 30 Gaotanyan Main Street, Chongqing, 400038, China.
  • 3. Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, 83 Xinqiao Main Street, Chongqing, 400037, China.
  • 4. Institute of Immunology, Third Military Medical University, 30 Gaotanyan Main Street, Chongqing, 400038, China. Electronic address: [email protected].
  • 5. Institute of Immunology, Third Military Medical University, 30 Gaotanyan Main Street, Chongqing, 400038, China. Electronic address: [email protected].
PMID: 39033553 DOI: 10.1016/j.bbrc.2024.150404
Abstract

The avermectin derivative doramectin is widely used clinically as an antiparasitic drug and, in addition, doramectin may have a modulatory role in Obesity. Adipose tissue macrophage recruitment and polarization play an important role in obesity-induced inflammation and Insulin Resistance. The aim of this study was to investigate the effects of doramectin on high-fat diet-induced inflammation and macrophage polarization in white adipose tissue of epididymis of obese mice. We found that compared with high-fat diet-fed obese mice, doramectin treatment resulted in a significant decrease in body weight and lipid levels, improved Insulin Resistance, an increase in the proportion of M2-type Macrophages and a decrease in the proportion of M1-type Macrophages in the epididymal white adipose tissues, as well as a decrease in the infiltration of inflammatory cells in the adipose tissues. Thus, doramectin can ameliorate high-fat diet-induced Obesity and adipose inflammation by affecting macrophage polarization in white adipose tissue.

Keywords
Adipose tissue; Doramectin; Insulin resistance; Macrophage polarization; Obesity.
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