Aluminum exposure impairs nuclear envelope breakdown for mouse zygote formation
- iScience. 2026 Apr 21;29(5):115807. doi: 10.1016/j.isci.2026.115807.
- 1. Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Reproductive Medicine of Guangxi Medical and Health Key Discipline Construction Project, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
- 2. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Aluminum exposure ubiquitously presents in the environment and its toxicity elicits oxidative stress and metabolic disorders. In the present study, we reported that aluminum exposure disturbed zygote formation with mouse model. We found that aluminum-exposed mouse zygotes exhibited nuclear envelope breakdown defects, indicative of failed zygote development. Further analyses revealed that microtubules decreased with aberrant tubulin acetylation, and Actin dynamics was disturbed, indicating the Cytoskeleton impairment. This further leads to DNA damage and disturbed cell cycle in zygotes. Moreover, mitochondrial dysfunction was observed, which triggers oxidative damage and Apoptosis. These defects were closely linked to the aberrant distribution and function of the organelles for protein modification and intracellular transport in zygotes. Collectively, our results indicate that aluminum exposure compromises cytoskeletal integrity and cell cycle progression, which may be due to mitochondria-based oxidative damage and Apoptosis for organelle function, and ultimately disrupts nuclear envelope breakdown for zygote formation in mice.