Novel 5,6-Bicyclic Compounds as 5‑HT2A Receptor Agonists for Treating Depression, Anxiety, Substance Abuse, and Headaches

  • ACS Med Chem Lett. 2026 Jun 3;17(7):1451-1452. doi: 10.1021/acsmedchemlett.6c00270.
Ram W Sabnis  1 ,  Anika R Sabnis  2
Affiliations
  • 1. Arclin USA LLC, 1150 Sanctuary Parkway, Suite 100, Alpharetta, Georgia 30009 United States.
  • 2. Department of Neurologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, United States.
PMID: 42445008 DOI: 10.1021/acsmedchemlett.6c00270
Abstract

Provided herein are novel 5,6-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse and headaches, and processes for preparing such compounds.

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