Application of the Salmonella typhimurium microsome test to the study of 25 drugs belonging to 5 chemical series

  • Mutat Res. 1980 Apr;77(4):301-6. doi: 10.1016/0165-1218(80)90001-4.
J Dayan ,  M C Crajer ,  S Bertozzi ,  S Lefrancois
PMID: 6990247 DOI: 10.1016/0165-1218(80)90001-4
Abstract

25 active-principle forms of pharmaceutical drugs belonging to 5 chemical series have been tested for mutagenic activity. To screen these drugs we used the Salmonella typhimurium assay on 5-histidine-requiring strains, with and without microsomal activation. Only the 3 nitroimidazole derivatives were mutagenic for strains TA100, TA1535 and TA98.

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