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Cat. No.: HY-146271

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pUL89 Endonuclease-IN-2

pUL89 Endonuclease-IN-2 (Compound 15k) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC₅₀ of 3.0 μM. Antiviral activities.

For research use only. We do not sell to patients.

CAS No.: 519021-48-8
Formula: C₁₇H₁₂F₃N₃O₃S
Molecular Weight:395.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

pUL89 Endonuclease-IN-2 Chemical Structure

CAS No.: 519021-48-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

pUL89 Endonuclease-IN-2 (Compound 15k) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC₅₀ of 3.0 μM. Antiviral activities^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	CC₅₀	43 μM Compound: 15k	Cytotoxicity against HFF cells assessed as cell viability incubated for 168 hrs by MTS-based Cell Titer assay Cytotoxicity against HFF cells assessed as cell viability incubated for 168 hrs by MTS-based Cell Titer assay	[PMID: 35377638]

In Vitro

Cell Viability Assay

Cell Line:

HFF cells
Concentration:

10 μM
Incubation Time:

168 hours
Result:

Inhibited HCMV replication in HFF cell with the EC₅₀ value of 14.4 μM.

Chemical Information

CAS No. 519021-48-8
Molecular Weight 395.36
Formula C₁₇H₁₂F₃N₃O₃S
SMILES

OC1=C(C(NCC2=CC=C(C(F)(F)F)C=C2)=O)N=C(C3=CC=CS3)N=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tianyu He, et al. 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. J Med Chem. 2022 Apr 14;65(7):5830-5849. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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