1. Others GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  2. Isotope-Labeled Compounds Histamine Receptor
  3. Levocetirizine-d4 dihydrochloride

Levocetirizine-d4 dihydrochloride  (Synonyms: (R)-Cetirizine-d4(dihydrochloride))

Cat. No.: HY-B0814S
Handling Instructions

Levocetirizine-d4 (dihydrochloride) is the deuterium labeled Levocetirizine. Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].

For research use only. We do not sell to patients.

Levocetirizine-d<sub>4</sub> dihydrochloride Chemical Structure

Levocetirizine-d4 dihydrochloride Chemical Structure

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Description

Levocetirizine-d4 (dihydrochloride) is the deuterium labeled Levocetirizine. Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].

IC50 & Target

H1 Receptor

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

465.83

Formula

C21H23D4Cl3N2O3

SMILES

OC(COC([2H])(C([2H])(N1CCN([C@@H](C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1)[2H])[2H])=O.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Levocetirizine-d4 dihydrochloride
Cat. No.:
HY-B0814S
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